October 2007

Edited by:
Dennis Scott BVSc MACVSc

Ethical Agents Ltd   54 Hobill Ave Wiri PO Box 97-110           SAMC

Ph 09-262-1388   Fax 09-262-1411        Freephone 0800 800-624
email eage@xtra.co.nz           website www.ethicalagents.co.nz

Who Are Troy Laboratories?

Inside this issue:

Troy Laboratories Pty. Ltd. is an Australian manufacturer of animal health products supplying the local and international market.

The company was founded in 1958 by a group of veterinarians with the objective to manufacture products to fulfil the specific requirement of the Australian market.

A decision was made that the products would be of the highest quality, that they would be presented in packs that provided convenient dosing and application for the user of the products and that they should be regarded as affordable.

By adhering to these three important principles, Troy Laboratories has not only survived over the past 49 years, but has indeed flourished and is nowadays considered one of the leading suppliers of veterinary products in Australia.

The company maintains an active product research and development program in association with external research organizations.

The company operates under the principles of Good Manufacturing Practice (GMP) and is licensed by the National Registration Authority (Licence No 1006).

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Special points of interest:

Notes on various topics from the excellent programme at WSAVA

The distinction between antisepsis and disinfection

An oral antibiotic with very high palatability

The facts on Meloxicam bioequivalence

Who Are Troy Laboratories?
1
Adjusting Doses in Renal Failure
1
Palatability Trials For Oral Medication
2
Putting faces To Our New Phone Voices
2
Cardiology Notes From WSAVA
3
More Notes From WASVA
4
Directions
4
Antisepsis v Disinfection
5
Wallaby Supporter
5
Meloxicam Bioequivalence
6
Bill and Tom
6
Dosage Regimen Adjustment (DRA) in Renal Failure
7

Its manufacturing and packaging capabilities extend to sterile injectable solutions and suspensions, creams, gels and ointments, oral nutritional products in liquid and powder form and insecticidal preparations.

Troy no longer just make simple generics, as shown by the Cephalexin Paste palatability trial outlined in page 2 of this newsletter and the Meloxicam bioequivalence data, in conjunction with the accurate delivery system described on page 6. In each case the reference product is improved upon.

Adjusting Dosages In Renal Failure

Half life is stable until glomerular filtration rate is down to 30-40% of normal.

i.e. OK until azotaemia

i.e. dose adjustment is only needed when 2/3 of renal function is lost.

Dose required = normal dose X increase in renal function

Dose interval = dose interval/increase in renal function,i.e. if the end point is ¼ of normal function then the dose is ¼ the normal dose, or the

dose interval is 4 times the normal dose interval.

Alternatively one can refer to the chart on the back page of this issue, which is available in colour and laminated from your area manager