June 2008
Edited
by:
Dennis Scott BVSc MACVSc
Ethical
Agents Ltd 54 Hobill Ave Wiri PO Box 97-110
SAMC
Ph 09-262-1388
Fax 09-262-1411 Freephone
0800 800-624
email eage@xtra.co.nz website
www.ethicalagents.co.nz
Inside this issue:
IA little knowledge is dangerous, an old adage that still holds true, especially when talking in the murky world of length of NSAID activity.
The idea that NSAIDs can be simply compared on half life ignores other factors that may prolong the activity of a drug in the body.
The half simply is a part of the measure of the decay curve of the drug over time but does not take into account other factors such as continued absorption or even re-absorption.
There is only one NSAID that can demonstrate therapeutic blood levels for as long as 48 hours and that is not because of simple half life.
The two major factors involved are entero-hepatic circulation, whereby the drug is excreted intact in the bile and reabsorbed via the intestine, in an ever decreasing circle, and, more importantly, the “flip flop” phenomenon of absorption.
This latter, despite the simple name, is a highly complex pharmacological process that applies to certain drugs.
It relies on complicated formulae dealing with the rate of absorption against the rate of elimination and so depends on I/M administration meaning that Tolfedine, and only Tolfedine, can give up to 48 hours therapeutic levels in the cow.
CalciTAD, why it alone has proof of efficacy and safety.
Aurizon®, one of the most exciting products to hit our shores.
Propercillin, a new dimension in injectable penicillin.
Applyte - tricking horses into drinking.
This, coupled with its strong central pain action and rapid onset make it the NSAID of choice in cattle medicine
Winter is here and the calving season is around the corner. As well as Calol and CalciTAD, both flattered by cheap imitations that do not have the same scientific trial work behind them,
two major product launches are featured in this issue.
Propercillin, a dynomilled penicillin injectable brings a new level of quality to this important market.
In addition the much awaited Aurizon®, the most prestigious ear preparation, is now available to our small animal practitioners.
This really is an exciting product from Vétoquinol.
