August 2006
Edited
by:
Dennis Scott BVSc MACVSc
Ethical
Agents Ltd 54 Hobill Ave Wiri PO Box 97-110
SAMC
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Sometimes referred to as E. coli mastitis, coliform mastitis is responsible for 50-70% of mastitis in the Northern hemisphere, but only about 2% in New Zealand.
Coliform mastitis is usually rapid in onset and shows obvious clinical signs. The mastitis is rarely subclinical. Often systemic symptoms are involved, including elevated temperature and loss of appetite.
Coliform mastitis is a serious problem where cows are confined indoors. Inorganic bedding material, e.g. sand or lime, help to reduce bacterial contamination of cow’s teats.
Increasing use of wintering or feed pads in New Zealand, particularly for lactating cows, may increase risk of this mastitis.
Although the 4th generation cephalosporin cefquinome is being mooted as a frontline therapy for coliform mastitis due to low MIC for E coli and pharmacokinetic factors in actual fact the 3rd generation fluoroquinolone marbofloxacin out performs it in both aspects.
The MIC for E coli for cefquinome is 0.391 µg/ml whereas for marbofloxacin it is much lower at 1.45 µg/ml..
* Length of anti-inflammatory action does not equate to length of analgesic properties.
* Regime of therapy for calf arthritis.
* High energy substrate contraindicated in osmotic diarrhoea (e.g. crypto or rotavirus)
Marbocyl—the specialist for coliform mastitis, calf arthritis, bacterial scours and respiratory disease
With a half life of 9 hours as opposed to 0.5 hours for cefquinome, marbofloxacin has a much longer level above MIC, especially considering the much greater penetrating ability of fluoroquinolones as opposed to ß lactams.
When comparing claims of NSAIDs in toxic shock one needs to be sure be sure of all the facts.
Because one claim of Tolfedine is at the double dose of 4 mg/kg this does not necessarily mean
that it is half as effective in toxic shock situations.
In fact this dose rate was used in a trial as a one-off treatment, as opposed to three days in a row with either flunixin or ketoprofen.
Tolfedine used this way was more effective than either of the other treatments.
Tolfedine in two normal doses a day apart was just as effective. These trials are summarised on page 2
